Presenilin 1(Phospho Ser357) Polyclonal Antibody, 20ul Pipette Controller The encoded protein is activated

The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation

The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor

and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events

In conjunction with p38 MAP kinase| this kinase is known to be involved in many cellular processes including stress and inflammatory responses| nuclear export| gene expression regulation and cell proliferation

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 20ul Pipette Controller The encoded protein is activatedAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.