Mouse Dedicator of Cytokinesis Protein 1, DOCK1 ELISA Kit, 96T Aspirating Pipets The genes of the alpha

The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation

while maintaining suppression of p53 transactivation and apoptotic functions

PubMed: 24132240)

It is thought to regulate transcription

Mutations in this gene result in Dystonia 3

Mouse Dedicator of Cytokinesis Protein 1, DOCK1 ELISA Kit, 96T Aspirating Pipets The genes of the alphaInvolved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.