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KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM)

It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP

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which may facilitate formation of heterotrimeric or multiprotein complexes

CHD8 Polyclonal Antibody, 20ul Hepatocytes Unleash your boldness with theThis gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.