CD6 Polyclonal Antibody, 50ul[BT-AP01805] Cell Labeling & Imaging EPS8L2 encodes a member of

EPS8L2 encodes a member of the EPS8 gene family

Members of this family are characterized by a highly conserved N-terminal J domain

which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns

which is the primary mechanism for the removal of cholesterol from the body

Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line

CD6 Polyclonal Antibody, 50ul[BT-AP01805] Cell Labeling & Imaging EPS8L2 encodes a member ofCIITA encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once