IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody, 50ul Thermal Control Mutations in this gene result

Mutations in this gene result in pseudohypoaldosteronism type IIB

RAD17 checkpoint clamp loader component recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage

ay play a role in vesicular transport from endoplasmic reticulum to Golgi

Supports IL-2 independent and IL-4 independent growth of helper T-cells

Strongly expressed after meiosis

IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody, 50ul Thermal Control Mutations in this gene resultThis receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have