GLI-1 Polyclonal Antibody, 100ul Peptide Library Increased expression of this gene

Increased expression of this gene leads to translocation of the encoded protein to the cell membrane

The protein contains a WAP-type four-disulfide core (WFDC) domain

but some of the chains have been shown to differ with respect to their tissue distribution

The BimEL and BimL isoforms may be sequestered to the dynein motor complex through an interaction with the dynein light chain and released from this complex during apoptosis

transferring phosphorus-containing groups and protein tyrosine kinase activity

GLI-1 Polyclonal Antibody, 100ul Peptide Library Increased expression of this geneThis gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.