Phospho PKC theta (Y90) Rabbit Polyclonal Antibody, 20ul Antibodies Mutations in BUB1 have been

Mutations in BUB1 have been associated with aneuploidy and several forms of cancer

tissue specificity:Expressed in skeletal muscle

and may be involved in pancreatic lithogenesis

Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half

This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription

Phospho PKC theta (Y90) Rabbit Polyclonal Antibody, 20ul Antibodies Mutations in BUB1 have beenCatalytic activity: ATP + a protein = ADP + a phosphoprotein. cofactor: Magnesium. The C1 domain containing the phorbol ester DAG type region 1 (C1A) and 2 (C1B) is the diacylglycerol sensor and the C2 domain is a non calcium binding domain. enzyme regulation: Three specific sites; Thr 538 (activation loop of the kinase domain) Ser 676 (turn motif) and Ser 695 (hydrophobic region) need to be phosphorylated for its full activation. PKC is activated by