DNA-PKCS Polyclonal Antibody, 100ul[BT-AP02673] Mechanical Pipette Cyclin dependent kinase inhibitor 1B

Cyclin dependent kinase inhibitor 1B binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes

Further regulation is represented by alternative splicing in the glutamine-rich activation domain

With cholesterol as its substrate| this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway

Alternatively spliced transcript variants encoding different isoforms have been observed

Mutations in this gene have been linked to exertional myoglobinuria

DNA-PKCS Polyclonal Antibody, 100ul[BT-AP02673] Mechanical Pipette Cyclin dependent kinase inhibitor 1BPRKDC (protein kinase, DNA activated, catalytic polypeptide) encodes the catalytic subunit of the DNA dependent protein kinase (DNA PK). It functions with the Ku70 Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3 PI4 kinase family.