TAB2(Phospho-Ser372) Rabbit Polyclonal Antibody, 20ul sgRNA Oligos Mutations in TSC2 lead to

Mutations in TSC2 lead to tuberous sclerosis complex

HIRA (histone cell cycle regulator) encodes a histone chaperone that preferentially places the variant histone H3

Pseudogenes of this gene are located on chromosomes 1 and X

It may have a role in the development of fragile X mental retardation syndrome

a severe disorder of renal tubular development

TAB2(Phospho-Ser372) Rabbit Polyclonal Antibody, 20ul sgRNA Oligos Mutations in TSC2 lead toThe protein encoded by this gene is an activator of MAP3K7 TAK1 which is required for for the IL 1 induced activation of nuclear factor kappaB and MAPK8 JNK. This protein forms a kinase complex with TRAF6 MAP3K7 and TAB1 and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein along with TAB1 and MAP3K7 also participates in the signal transduction induced by TNFSF11 RANKl through the activation of the receptor activator of NF kappaB