Human Atp-binding Cassette Sub-family G Member 8, ABCG8 ELISA Kit, 96T 3D Cell Culture Consumables These apparently intronless genes encode

These apparently intronless genes encode a 7-transmembrane receptor protein

Mutations in this gene cause familial cold autoinflammatory syndrome type 2

Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions| while up-regulation of this gene has been observed in colorectal cancers

The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled| a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin

An important paralog of this gene is ZNF229

Human Atp-binding Cassette Sub-family G Member 8, ABCG8 ELISA Kit, 96T 3D Cell Culture Consumables These apparently intronless genes encodeABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+) and ATP dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed: 11099417, PubMed: 11452359, PubMed: 27144356, PubMed: 15054092). Required for normal sterol homeostasis (PubMed: 11099417, PubMed: 11452359, PubMed: