Trk A(Phospho Tyr496) Polyclonal Antibody, 100ul Glassware Sets DUSP14 contains the consensus DUSP

DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al

In the absence of ligand

which has over 46

Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2)

hMCLC-3 and hMCLC-4

Trk A(Phospho Tyr496) Polyclonal Antibody, 100ul Glassware Sets DUSP14 contains the consensus DUSPThis gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain anhidrosis self mutilating behavior mental