Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Eight alternatively spliced transcript variants

Eight alternatively spliced transcript variants have been described

A second copy of this gene within the centromeric copy of the duplication has been described in the literature

The protein may also be involved in the pathophysiology of depression

Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells

Mutations in this gene are associated with generalized glucocorticoid resistance

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Eight alternatively spliced transcript variantsThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.