Rat Interleukin 18, IL-18 ELISA Kit, 96T Digital Burette It is able to bind

It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner

and may be involved in cancer

The encoded protein was originally described in bile ducts of liver as biliary glycoprotein

Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane

May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity)

Rat Interleukin 18, IL-18 ELISA Kit, 96T Digital Burette It is able to bindA proinflammatory cytokine primarily involved in polarized T helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF kappa B, triggering synthesis of inflammatory mediators. Synergizes with IL12 interleukin 12 to induce IFNG synthesis from T helper 1 (Th1) cells and natural killer (NK) cells.