H2A2B Rabbit Polyclonal Antibody, 50ul Diagnostic Probes & Oligos This gene encodes a 28S

This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members

The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53

Catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

Defects in this gene are associated with cell proliferation in certain cancers

The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease

H2A2B Rabbit Polyclonal Antibody, 50ul Diagnostic Probes & Oligos This gene encodes a 28SHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A H2B H3 and H4). The chromatin fiber is further compacted through the interaction of a linker histone H1 with the DNA between the nucleosomes to form higher order chromatin structures. This