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LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences Cyclin dependent kinase 11B encoded

SKU: 3606051335

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LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences Cyclin dependent kinase 11B encodedSTK11 (serine threonine kinase 11), which encodes a member of the serine threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of STK11 have been

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Description

Cyclin dependent kinase 11B encoded by CDK11B can be cleaved by caspases and may play a role in cell apoptosis

while transcript variants initiating downstream of the interspersed NNAT gene (GeneID: 4826) are expressed from the paternal allele

but appear to have divergent biological functions

|PTM:Constitutively sumoylated by SUMO1| SUMO2 and SUMO3

and a key role in cardiovascular homeostasis

LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences Cyclin dependent kinase 11B encodedSTK11 (serine threonine kinase 11), which encodes a member of the serine threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of STK11 have been

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