c-Myc(Phospho Thr58) Polyclonal Antibody, 20ul Antibodies This gene is located in

This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer

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Two transcript variants encoding different isoforms (B and B') have been found for this gene

SPHK2 (sphingosine kinase 2) encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate

The encoded protein plays an important role in maintaining stem cell populations| and may be aberrantly expressed in tumor cells

c-Myc(Phospho Thr58) Polyclonal Antibody, 20ul Antibodies This gene is located inThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is