Microcephalin Polyclonal Antibody, 50ul Pathway and Network Analysis Members of the WIPI subfamily

Members of the WIPI subfamily of WD40 repeat proteins| such as WIPI2| have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al

Members of this family are believed to be involved in embryogenesis

The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit

tissue specificity:Expressed at the highest level in both brain and testis

prostaglandin-endoperoxide synthase 1 has been identified as a moonlighting protein

Microcephalin Polyclonal Antibody, 50ul Pathway and Network Analysis Members of the WIPI subfamilyThis gene encodes a DNA damage response protein. The encoded protein may play a role in G2 M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.