Shc(Phospho Tyr427) Polyclonal Antibody, 20ul Biomatrix and mutations in that gene

and mutations in that gene can abolish interaction with negative regulator of ubiquitin like proteins 1

which are small GTPases involved in protein transport

Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production

The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions

It is an adaptor protein localized in the nucleus

Shc(Phospho Tyr427) Polyclonal Antibody, 20ul Biomatrix and mutations in that geneThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.