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ACOT8 Polyclonal Antibody, 20ul Vector Construction a game-changing accessory for yourAcyl CoA thioesterase 8 encoded by ACOT8 is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus 1 protein Nef, and mediate Nef induced down regulation of CD4 in T cells.