BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody, 50ul Cell Culture & Maintenance epigenetic silencing of SFRP genes

epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer

H2AFZ interacts with INCENP

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels

A snoRNA gene (SNORD61) is found in one of its introns

Chromosome 19

BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody, 50ul Cell Culture & Maintenance epigenetic silencing of SFRP genesThis gene belongs to the ubiquitin C terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition the enzyme may be involved in regulation of transcription regulation of cell cycle and growth response to DNA damage and chromatin