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RASA1 Polyclonal Antibody, 100ul Pasteur Pipets This gene and its co-chaperonin

SKU: 27970589576

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RASA1 Polyclonal Antibody, 100ul Pasteur Pipets This gene and its co-chaperoninThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP bound form of RAS, thereby allowing control of cellular proliferation and

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Description

This gene and its co-chaperonin

Additional transcript variants have been described in publications but their full-length sequence has not been determined

Mutations in this gene are a cause of the H-Bombay blood group

This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule

One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies

RASA1 Polyclonal Antibody, 100ul Pasteur Pipets This gene and its co-chaperoninThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP bound form of RAS, thereby allowing control of cellular proliferation and

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