DMGDH Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Alternative splicing of PIK3R1 results

Alternative splicing of PIK3R1 results in four transcript variants encoding different isoforms

such as pyrimidine-4-aldehyde

Ser-1029 or Ser-1031 is important for cytoplasmic export

which impairs its recruitment to the TCR and subsequent activation

Contains 1 kinesin-motor domain

DMGDH Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Alternative splicing of PIK3R1 resultsDMGDH encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme (dimethylglycine dehydrogenase) is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of