PLB Polyclonal Antibody, 100ul Immunology It is localized to the

It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region

disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2)

as well as KRTHB3 and KRTHB6

possibly acting as the signal that turns on the membrane fusion machinery

and it therefore likely functions in spermatid formation

PLB Polyclonal Antibody, 100ul Immunology It is localized to theThe protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+) ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the