PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification The cytogenetic location of this

The cytogenetic location of this locus has been reported as both 8p11 and 8q11

an alpha chain (GP1BA

and to a lesser degree

RNA polymerase III subunit A encoded by POLR3A is the catalytic component of RNA polymerase III

Expressed specifically in the hippocampus and Purkinje cells of the brain

PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification The cytogenetic location of thisCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB AKT, but also PKA, PKC zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM: Phosphorylated on tyrosine and serine threonine. Phosphorylation on Ser 241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser 241,