Cables1 Polyclonal Antibody, 50ul Gloves This gene is clustered among

This gene is clustered among 4 other ABC1 family members on 17q24| but neither the substrate nor the function of this gene is known

PTM:Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) is a Protein Coding gene

The encoded protein has been linked to metastatic breast cancer

Alternative splicing generates two mRNA variants

Cables1 Polyclonal Antibody, 50ul Gloves This gene is clustered amongCABLES1 encodes a protein (Cdk5 and Abl enzyme substrate 1) involved in regulation of the cell cycle through interactions with several cyclin dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding