GLI-1 Polyclonal Antibody, 20ul Long RNA Synthesis The C region genes are

The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14

Alternatively spliced transcript variants have been identified for NBL1

mutations in this gene are thought to confer a predisposition to sarcomas

subcellular location:Seems to be excluded from nucleoli

and is used as a fluorescent tracer in trasfection and transgenic experiments

GLI-1 Polyclonal Antibody, 20ul Long RNA Synthesis The C region genes areThis gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.