Rb Polyclonal Antibody, 50ul[BT-AP07690] Nucleic Acid Extraction Also detected in lung and

Also detected in lung and testis

Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies

the protein was only detected in CD34+ progenitor cells present in blood and in CD31+ endothelial cells surrounding the blood vessels

tissue specificity:B-cell specific

and ensures operating safety

Rb Polyclonal Antibody, 50ul[BT-AP07690] Nucleic Acid Extraction Also detected in lung andThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.