DNA Ligase I Polyclonal Antibody, 20ul Reservoirs Polymorphisms in CFB are associated

Polymorphisms in CFB are associated with a reduced risk of age-related macular degeneration

This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat

An extremely rare recessive genetic disorder

but the exact function of the encoded protein is unknown

thereby affecting various biological functions

DNA Ligase I Polyclonal Antibody, 20ul Reservoirs Polymorphisms in CFB are associatedLIG1 encodes a member of the ATP dependent DNA ligase protein family. DNA ligase 1 functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA damaging agents. Disruption of LIG1 may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.