PMEPA1 Polyclonal Antibody, 20ul Yeast Expression CEACAM3 encodes a member of

CEACAM3 encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs)

IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta

Although its endogenous substrate has not been determined

Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates

Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb

PMEPA1 Polyclonal Antibody, 20ul Yeast Expression CEACAM3 encodes a member ofPMEPA1 encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of PMEPA1 is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of PMEPA1 may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple