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The encoded protein is a member of the T-box 1 subfamily

It contains an N-terminal caspase recruitment domain (CARD)| a centrally located nucleotide-binding domain (NBD)| and 10 tandem leucine-rich repeats (LRRs) in its C terminus

CASP8 cleaves BH3-interacting domain death agonist

Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy| in particular limb-girdle muscular dystrophy| type 2C (LGMD2C)

CD58 Polyclonal Antibody, 50ul[BT-AP01843] Antibody Humanization Say goodbye to spills andCLDN2 (claudin 2) product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ specific manner and regulate tissue specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for CLDN2.