MRE11 Polyclonal Antibody, 20ul[BT-AP05547] Enzyme Activity Assays Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have been identified in this gene

One of several members of the Ser/Thr protein kinase family

that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5

reproductive

Alternate splicing of this gene results in two transcript variants encoding different isoforms

MRE11 Polyclonal Antibody, 20ul[BT-AP05547] Enzyme Activity Assays Alternatively spliced transcript variants encodingMRE11A encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA