Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies Knockout studies in mice suggested

Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure

some of which encode the same protein

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit

Contains 1 CCHC-type zinc finger

Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms

Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies Knockout studies in mice suggestedThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.