IRPL1 Polyclonal Antibody, 100ul Cell Senescence Mutations in ITCH are a

Mutations in ITCH are a cause of syndromic multisystem autoimmune disease

The protein encoded by MED14 (mediator complex subunit 14) is a subunit of the CRSP (cofactor required for SP1 activation) complex

lacking an intracellular serine/threonine kinase domain required for signaling

CSRP1 encodes a member of the cysteine-rich protein (CSRP) family

but specific functions of the protein have not been determined

IRPL1 Polyclonal Antibody, 100ul Cell Senescence Mutations in ITCH are aThe protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X linked non syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is