NALP2 Polyclonal Antibody, 100ul Cellular Function Assays and cell transformation

and cell transformation

PTM:Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes

Mutations in this gene have been associated with insulin-dependent diabetes mellitus

and also play critical roles in maintaining cell polarity and signal transductions

The N-terminal half of this protein is required for its centrosome localization and for its multimerization

NALP2 Polyclonal Antibody, 100ul Cellular Function Assays and cell transformationNALP proteins, such as NALP2, are characterized by an N terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase 1 (CASP1; MIM 147678) by Toll like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003