SIK1 Polyclonal Antibody, 50ul[BT-AP14226] Buffer Solutions functions as an E1-like activating

functions as an E1-like activating enzyme in a ubiquitin-like conjugating system

In vitro phosphorylated by PKC

Mutations in this gene are found in patients diagnosed with Stargardt disease| a form of juvenile-onset macular degeneration

and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells

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SIK1 Polyclonal Antibody, 50ul[BT-AP14226] Buffer Solutions functions as an E1-like activatingCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,cofactor: Magnesium.,enzyme regulation: Activated by phosphorylation on Thr 182 by STK11 in complex with STE20 related adapter alpha (STRAD alpha) pseudo kinase and CAB39.,Transient role during the earliest stages of myocardial cell differentiation and or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and or differentiation. Potential