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11,12,13 Loss of -cell identity has been consistently observed in mouse models, 9 non-human primates, 14,15 and patients with T2D, 16,17,18,19,20 characterized by a reduction in cells, together with an increase in cells and bi-hormonal INS + GCG + cells

Leeson-Payne, A

10.1080/13803395.2019.1611741 J

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Global analysis of the mitochondrial proteome in response to cellular GSH depletion To identify mitochondrial proteins regulated by GSH availability, we used quantitative proteomics and analyzed mitochondria immunopurified from HeLa cells expressing a mitotag (3XHA-OMP25-mCherry) grown in standard media or treated with the glutathione synthesis inhibitor, buthionine sulfoximine (BSO) 13