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Clinically, AF patients show significantly reduced atrial mitochondrial ATP levels and elevated oxidative stress when compared to individuals with normal sinus rhythm

The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications

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de Candia, P., & Matarese, G

Experimental studies reported that procedures like choline-induced fecal transplantation from one person to another can also transfer the risk of developing atherosclerosis [69, 75]

Furthermore, Nrf2 activators reduce the extent of neuronal death caused by iron overload, most likely by regulating genes associated with iron metabolism and the synthesis of antioxidants that protect cells from oxidative stress and ferroptosis [48, 49]