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To account for missing outcome data at different follow-up time points, Inverse Probability Weighting (IPW) models were utilized based on the extended set of 42 baseline covariates and available outcomes as predictors

And, each one has its own safety profile

Mov Disord 2015;30(12):1696-1701

The direct healthcare costs related to individuals who are overweight or obese with associated comorbidities are $480 billion, and lost productivity surpasses $1 trillion, according to nonprofit economic think tank the Milken Institute