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Instead of one drug, one disease, we should think of designing drugs that impact multiple diseases.

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NAC can cause nausea, vomiting, and diarrhea at higher doses

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They suspected that the phenomenon might be down to a substance in the gut like 'the hypothetical incretin' (Samols, Marri, Marks 1966

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[DOI] [PubMed] [Google Scholar] Griese M, Ramakers J, Krasselt A, Starosta V, Van Koningsbruggen S, Fischer R, Ratjen F, Mllinger B, Huber RM, Maier K, Rietschel E, Scheuch G

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TLR7 agonist RO7020531 triggers immune activation after multiple doses in chronic hepatitis B patients [abstract]

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Khafagy et al., 2009b)

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