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However, in a recent phase II study following up on the study by Fleming et al

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Our bodies are able to naturally produce GSH, however, production decreases with age, and we can quickly become overwhelmed with toxins and other offenders that deplete it

Your body then releases glutathione (and other antioxidants) to scavenge for free radicals and quench their effect, depleting overall levels if your body can't keep up with the glutathione demand

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Pharmacological potential of three berberine-containing plant extracts obtained from Berberis vulgaris L., Mahonia aquifolium (Pursh) Nutt., and Phellodendron amurense Rupr