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Preclinical studies included in the review showed the following actions of GLP-1 analogs in psoriasis: decrease in interferon-gamma and interleukin-4 in a dose-dependent manner decrease in interleukin-6, tumor necrosis factor-alpha, and lipopolysaccharide-induced inflammation reduction in keratinocyte proliferation and macrophage migration The review also included human data to determine whether GLP-1 analogs have a role in treating inflammatory arthritis and psoriasis

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It is the most abundant amino acid in both intracellular and extracellular compartments produced by the action of glutamine synthase as it is required for number of cellular functions

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