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Discussion Paradigm shift in medicine: interconnected metabolomics The onset of studies into TMAO and its widespread effects on the human body marks a paradigm shift in medicine, with growing interest in gut-derived metabolites such as TMAO reflecting a broader shift toward viewing disease as a product of interconnected metabolic networks

103,104 Besides, ME2 ablation results in elevated cellular ROS levels, which activates the AMPK pathway and then stimulates TP53 to attenuate melanoma cell proliferation

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10.1038/s41413-020-0100-9 176 NiX.HuL.ZhangX.WangZ.YanC.PeyrodieL.et al (2024)

It occurs when excess sebum binds pollutants, dirt, and dead cells to the skins surface, leading to clogged pores

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