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2DF, dose-dependent treatment with SP reduced the proportions of M1-like macrophages as well as increased the proportions of anti-inflammatory M2-like macrophages (mannose receptor CD206 as the phenotypic marker of M2-like macrophages), suggesting that SP inhibited the polarization of proinflammatory M1-like macrophages and promoted the differentiation of anti-inflammatory M2-like macrophages

10.1016/j.phymed.2020.153211 96 YangY.ChenJ.GaoQ.ShanX.WangJ.LvZ

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In addition, Nrf2 regulates proteasomal protein degradation (83), cell proliferation (84), and metabolic reprogramming (85), which are not discussed in this review

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