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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

Neurochem Res 42:32203232 Clark AJ, Davis ME (2015) Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

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It is important to note however the results from the knock-in model is not in line with an earlier post-mortem human ad brain study in which decreased expression of GAT transporters was reported [100], although GAT investigated in human study was not astrocytic specific [100]

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