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For reference ATTAIN-1 reported an 11.2% body-weight loss for Orfoglipron

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MAPK/ERK Cascade and GILZ Homology Computational and molecular research identified structural homology between DSIP and GILZ (glucocorticoid-induced leucine zipper) a glucocorticoid-regulated protein that prevents Raf-1 activation and thereby inhibits ERK phosphorylation via the MAPK cascade