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Finally, when all typical non-operative treatments have been exhausted and a patient is still experiencing significant pain, a referral to spine surgery may be considered for further evaluation and possible surgical intervention

These side effects often decrease over time as your body adapts to the medication

As a protease, HDAC2 plays an important role in the modification of chromosome structure and regulation of gene expression and is related to the deacetylation of a variety of transcription factors, receptors and histones

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Carboplatin has minimal ototoxicity at conventional doses (risk elevated only at 2000 mg/m 2 or intrathecal administration) (McKeage 1995), while oxaliplatin, nedaplatin and lobaplatin have weak cochlear affinity and rare ototoxicity (Hellberg et al