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In a placebo-controlled, double-blind phase I study of ascending doses of cotadutide, there were dose-dependent improvements in glycemic control and increased satiety [45]

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This directly impacts point #1, and the goal of the article is precisely to discredit this narrative

569 Their chemical structure, dosage form, and administration route are the main determinants of their absorption, distribution, metabolism, and excretion, thereby affecting their efficacy and safety