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The upregulation of miR-21 in macrophages, the key cells of the inflammatory response in MASLD, has been associated with a systemic inflammatory response and increased production of proinflammatory cytokines such as IL-1, TNF, and IL-6 [311]

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The same reservoir delivers 24 events at the 2.5mg starting increment used in SURPASS-1 through SURPASS-6 (20212023), where dose was raised by 2.5mg every four weeks to a maximum of 15mg weekly [2]