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The Canadian product monograph for Depo-Provera explicitly warns: Meningiomas have been reported following long-term administration of progestins, including medroxyprogesterone acetate (MPA) . Additionally, the accompanying drug information advises physicians to exercise caution when prescribing Depo-Provera to patients with a history of meningiomas and to discontinue its use immediately if a patient develops a meningioma

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