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Serum requires clotting before analysis, whereas plasma can be measured immediately as the samples are collected in heparinized tubes [45]

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In patients with intraoral carcinoma, cervical lymph node involvement is evident at diagnosis in 30% of cases and occult in 10% to 40% of cases.4,7 Verrucous carcinoma (oral florid papillomatosis) Verrucous carcinoma is a low-grade variation of oral squamous cell carcinoma that typically affects individuals over the age of 55 with a habit of chewing snuff and tobacco.4 The lesion appears as a thick, diffuse, well-defined, painless plaque with papillary or verrucous projections on the surface (Fig